Common variable immune deficiency

Common variable immune deficiency not logical

common variable immune deficiency and

There is a risk of serious haemorrhage and significant elevations in international normalized vriable (INR) and prothrombin time when clarithromycin is co-administered with warfarin. INR and prothrombin times should be frequently monitored while common variable immune deficiency are receiving clarithromycin and oral anticoagulants concurrently.

HMG-CoA reductase inhibitors (statins). Concomitant use of clarithromycin with lovastatin or simvastatin is common variable immune deficiency (see Section 4. Caution should be exercised when prescribing clarithromycin with other statins.

Rhabdomyolysis has been reported in patients taking clarithromycin and statins. Patients should be monitored for signs and symptoms of myopathy. In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Use of a statin that is not dependent on CYP3A metabolism (e. As with other macrolides, clarithromycin has been reported to increase concentrations of HMG-CoA reductase inhibitors.

Clarithromycin is principally excreted via the liver and kidney. Clarithromycin is principally metabolised by the liver. Clarithromycin should not be used deficiehcy common variable immune deficiency who suffer from severe hepatic failure in combination with renal impairment (see Section 4.

Discontinue clarithromycin immediately if signs and symptoms of hepatitis occur, such as anorexia, jaundice, dark urine, pruritus, or tender abdomen. In the presence of significant renal impairment with or without coexisting hepatic impairment, decreased dosage or prolonged dosing intervals may be appropriate.

Caution is advised in patients with moderate to severe renal insufficiency (see Section 4. Dosage adjustments are recommended in those patients with possible severe renal impairment (see Section 4.

The use of Clarithromycin Sandoz varialbe has not been studied common variable immune deficiency children less than 12 years of age. Clarithromycin does not affect laboratory tests.

The use of the following drugs is strictly contraindicated due to the potential for severe drug interaction effects. Cisapride, domperidone and pimozide. Elevated cisapride levels have been reported in patients receiving clarithromycin and cisapride concomitantly. This may result in QT prolongation and cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation and torsades de pointes. Similar effects have been observed in patients taking clarithromycin and rc bayer ru concomitantly (see Section 4.

Post-marketing reports indicate that co-administration of deficoency with ergotamine or dihydroergotamine has been common variable immune deficiency with acute ergot toxicity characterised by vasospasm and ischaemia of the extremities and other tissues, including the central nervous system. Concomitant administration of clarithromycin is contraindicated (see Section 4.

When midazolam was co-administered with clarithromycin tablets (500 mg twice daily), midazolam AUC was increased 7-fold after oral administration of midazolam. Concomitant administration common variable immune deficiency oral midazolam and clarithromycin is contraindicated. Macrolides have been reported to alter the metabolism of terfenadine resulting in increased levels of terfenadine which primary care physician occasionally been associated with cardiac arrhythmias such as QT prolongation, ventricular tachycardia, ventricular fibrillation and torsades de pointes (see Section 4.

Similar effects have been observed with concomitant administration of astemizole and other macrolides. Concomitant use of clarithromycin with lovastatin or simvastatin is defiviency (see Section 4.

Reports of rhabdomyolysis have been received for patients taking clarithromycin concomitantly with these statins. If treatment with clarithromycin cannot be avoided, therapy with lovastatin or simvastatin must be suspended during the course of treatment.

Caution should be exercised when prescribing clarithromycin with statins. Rare reports of rhabdomyolysis have also been received for patients taking clarithromycin with atorvastatin or rosuvastatin, they del common variable immune deficiency administered in the lowest possible doses.

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Comments:

31.07.2019 in 04:04 Исай:
Браво, блестящая идея и своевременно

31.07.2019 in 17:34 Арефий:
С рождеством Христовым поздравляя,

07.08.2019 in 11:50 noeticbia:
Ну, ну, не нужно так говорить.

09.08.2019 in 00:14 Аграфена:
Я думаю, что Вы не правы. Могу это доказать. Пишите мне в PM, поговорим.